PRODUCT INFORMATION SHEET
METAGESTON DEPOT-250/500 INJECTION
METAGESTON DEPOT-250/500 INJECTION is a derivative of Progesterone which is the main hormone secreted by the corpus luteum. Large quantities are naturally produced by the placenta during pregnancy. It acts on the endometrium and prepares the uterus for nidation i.e. to receive the fertilised ovum. METAGESTON DEPOT-250/500 INJ. contains Hydroxy Progesterone Caproate B.P. 250 mg per ml Injection. (Packing 250=1ml & 500=2ml)
USES & INDICATIONS :
METAGESTON DEPOT INJ. is the derivative of the main hormone secreted by the corpus luteum and thus is indicated and useful for :
* Preparing the uterus for NIDATION
* Helps in maintainence of Pregnancy
* For Menstrual Disorders and irregularities such as dysmenorrhoeae and menorrhagia (dysfunctional uterine
* Post Menopausal disorders
* Breast and endometrial carcinomas
* Habitual & Threatened Abortions
* Infertility due to corpus luteum insufficiency
* Uterine Hypoplasia
ADVERSE EFFECTS & PRECAUTIONS :
METAGESTON DEPOT INJ. should be used with caution in patients with cardiovascular or renal impairment, diabetes mellitus, asthma, epilepsy and migraine, or other conditions which may be aggravated by fluid retention. It should be used with care in patients with a history of mental depression and should not be given in patients with undiagnosed vaginal bleeding. Its side effects may include gastro-intestinal disturbances. change in appetite or weight, fluid retention, edema, acne, melasma or chloasma, allergic skin rashes, changes in breast, fatigue etc.
In Habitual Abortions associated with progesterone deficiency METAGESTON DEPOT INJ. is recommended in a 250 to 500 mg weekly dose by a slow intramuscular injection. Higher dose may be needed in severe cases as per the physicians discretion.