PERK

PRODUCT INFORMATION

 NOROSOL TABLETS, NOROSOL - M SUSPENSION & NOROSOL - T TABLETS

NOROSOL range of products includes NOROSOL TABLETS (Norfloxacin 400 mg) NOROSOL - M SUSPENSION and NOROSOL - T TABLETS.

NOROSOL TABLETS contains Norfloxacin 400 mg. NOROSOL-M Susp. contains Norfloxacin with the time tested anti-amoebic Metronidazole. Norosol-M Suspension (30 ml) contains Norfloxacin 100 mg and Metronidazole (as Benzoate) 100 mg in each 5 ml. NOROSOL-T TABLETS contains Norfloxacin 400 mg and Tinidazole 600 mg. (Blisters of 10 X 10 Tablets).

USES :

NOROSOL GROUP contains Norfloxacin which is a fluorinated 4-quinolone anti-microbial agent structurally related to nalidixic acid but with a wider and much stronger antibacterial spectrum and greater activity. Administration of Norfloxacin by mouth readily produces urinary concentrations that are bactericidal to most urinary tract pathogens, including Pseudomonas aeruginosa. In Enteric Tract Infections and Gastro Enteritis NOROSOL GROUP  has shown a tremendous response with all sorts of Bacterial and Mixed Gastro Enteritis, Diarrhoea, Amoebiasis, Giardiasis and in Urinary Tract Infections.

RATIONALE OF NOROSOL GROUP COMBINATIONS :

There have been many studies on the antimicrobial activity in vitro of Norfloxacin,  Metronidazole and Tinidazole and some have been subject to detailed reviews (S.W.B. Newsom, J. antimicrob. Chemother., 1984, 13, Suppl. B,25; B. Holmes et al., Drugs,  1985, 30, 482). It has been shown that all are Bactericidal and Anti- Protozoal. Metronidazole and Tinidazole in particular are active against several protozoa including Balantidium Coli, Blastocystis hominis, Entaamoeba histolytica, Giardia intestinalis (Giardia lamblia), and Trichomonas vaginalis. (Martindale, The Extra Pharmacopoeia, 29th Edition)

The point to be noted in the therapy with NOROSOL GROUP is that the basic therapy is of Norfloxacin in all cases and as an adjuvant we are including Metronidazole and Tinidazole. For Mild to Moderate Infections NOROSOL 400 mg tablets are suggested for best action. For Moderate to Severe Infections NOROSOL-M Suspension (Norfloxacin with Metronidazole) has shown to be most effective. For Severe Infections NOROSOL-T TABLETS (Norfloxacin with Tinidazole) has shown the best results.

In NOROSOL-T TAB. the half lives of both Norfloxacin and Tinidazole are quite suited to a daily dose of 2 tablets. As for NOROSOL-M Susp. it has noticed that Metronidazole has a synergistic action in conjunction with Norfloxacin and hence lower doses are most suited for Moderate Infection as are most prevalent in India. The lower dose of Metronidazole in a 12 hourly dose has shown appreciable results. Doctors are therefore requested to try the free samples given by our representatives in their patients and judge for themselves the remarkable therapeutic action of this dosage form. Kindly also note that this dosage form is the  most effective in the Moderate Infections which are most prevalent in Indian Conditions.

For Pediatric Patients NOROSOL-M SUSPENSION has shown excellent to life saving response since its launch in all Moderate to Severe Infections in children. The dosage varies from 5ml three to five times daily depending upon the severity of the patient.

INDICATIONS :

NOROSOL GROUP is indicated in Diarrhoeae, Dysentery, Bacterial and Mixed Gastro Enteritis, Amoebiasis, Giardiasis, Protozoal Infections, and Urinary Tract Infections.

CONTRA INDICATIONS & PRECAUTIONS :

NOROSOL GROUP should be given with care in patients with damage of central nervous system, to patients subject to convulsions, and to those with impaired renal or hepatic function. It should be avoided in babies less than 3 months old. Patients should avoid direct sunlight during treatment. It may cause false-positive reactions in urine test for glucose using copper reduction methods. It should be used with great care in patients with blood dyscrasias. It should be avoided during pregnancy, especially first trimester and during lactation. Patients should maintain adequate Fluid Intake during Treatment.

DOSAGE :

The total Group of NOROSOL including NOROSOL-T are given in dose of 1 tablets BD for 7 to 10 days. The product is chosen on the severity of infection as detailed above. NOROSOL-M Suspension is given in a dose of 5 ml (1 teaspoon)  three to five times daily depending upon the severity of Infection.

HOME     BACK